The purpose of this project is to investigate both the toxic and protective effects of curcumin-coated gold nanoparticles (Cur-AuNPs) in a PD model. Specifically, the project aims to determine whether Cur-AuNPs can protect neurons from degeneration, reduce oxidative stress, and improve motor functions. If successful, this approach could be a potential therapy for Parkinson’s disease, which currently relies on treatments that only manage symptoms and often come with side effects. By combining natural compounds like curcumin, with advanced nanomaterials, this project explores a novel, biocompatible strategy to address neurodegenerative diseases such as Parkinson’s.