Taught by Dr. Crowthers, this course centers around scientific research, engineering design, and clear technical communication. In this first part of the class, we conduct independent research projects involving literature review, experimental design, data analysis, and presentation, culminating in a school-wide science fair with opportunities for advancement to higher-level competitions.
This project examines how altering the insulin signaling pathway affects neurodegeneration in an Alzheimer’s disease (AD) like model using Drosophila melanogaster. AD is closely linked to metabolic dysfunction and insulin resistance, yet insulin signaling in the brain plays a complex, dual role in neuronal health. Using aging, metabolic stress, and traumatic brain injury to induce Alzheimer’s-like pathology, this study genetically reduces insulin signaling via chico knockdown or increases it through insulin receptor overexpression. Neurodegeneration will be assessed through behavioral assays measuring locomotion, memory, and aggression. The central hypothesis is that reduced insulin signaling will be neuroprotective, while elevated signaling will worsen neurodegenerative outcomes.
This quad chart details the goal, methodology, and current results of my STEM project so far.