STEM Project Proposal

Importance of Research

This research is significant due to the growing global health threat of antibiotic resistance, which makes infections that were once easily treatable with antibiotics increasingly difficult to manage. As antibiotic-resistant bacteria continue to rise, they lead to higher mortality rates, longer hospital stays, and increased healthcare costs. Traditional approaches to combating bacterial infections are becoming less effective, emphasizing the need for innovative strategies to enhance the effectiveness of existing antibiotics. This study focused on natural compounds like 1,8-Cineole (Eucalyptol) and Naringenin as potential antibiotic adjuvants to help combat resistance. Our findings reveal that Eucalyptol demonstrated a synergistic effect when combined with Azithromycin, enhancing its effectiveness against Escherichia coli. This result underscores the potential of combining natural compounds with antibiotics to counteract resistance mechanisms, potentially restoring the efficacy of antibiotics that are becoming less effective over time. By identifying such synergistic interactions, this research opens up promising avenues for addressing the escalating issue of antimicrobial resistance, offering a strategy to improve treatment outcomes for infections caused by resistant pathogens, and potentially saving millions of lives worldwide.

Grant Proposal