**MA540/MA4631 Probability and Mathematical Statistics I**

Intended for advanced undergraduates and beginning graduate students in the mathematical sciences, and for others intending to pursue the mathematical study of probability and statistics. Topics covered include axiomatic foundations, the calculus of probability, conditional probability and independence, Bayes Theorem, random variables, discrete and continuous distributions, joint, marginal and conditional distributions, covariance and correlation, expectation, generating functions, exponential families, transformations of random variables, types of convergence, laws of large numbers the Central Limit Theorem, Taylor series expansion, the delta method. (Prerequisite: knowledge of basic probability at the level of MA 2631 and of advanced calculus at the level of MA 3831/3832 is assumed.)

Class materials are given at the web-based blackboard myWPI.

**MA541/MA4632 Probability and Mathematical Statistics II**

This course is designed to provide background in principles of statistics. Topics covered include estimation criteria: method of moments, maximum likelihood, least squares, Bayes, point and interval estimation, Fisher?s information, Cramer-Rao lower bound, sufficiency, unbiasedness, and completeness, Rao-Blackwell Theorem, efficiency, consistency, interval estimation pivotal quantities, Neyman-Person Lemma, uniformly most powerful tests, unbiased, invariant and similar tests, likelihood ratio tests, convex loss functions, risk functions, admissibility and minimaxity, Bayes decision rules. (Prerequisite: knowledge of the material in MA 540 is assumed.)

Class materials are given at the web-based blackboard myWPI.

**BCB540/BCB4004/MA584/MA4603 Statistical Methods in Genetics and Bioinformatics**

This course provides students with knowledge and understanding of the applications of statistics in modern genetics and bioinformatics. The course generally covers population genetics, genetic epidemiology, and statistical models in bioinformatics. Specific topics include meiosis modeling, stochastic models for recombination, linkage and association studies (parametric vs. nonparametric models, family-based vs. population-based models) for mapping genes of qualitative and quantitative traits, gene expression data analysis, DNA and protein sequence analysis, and molecular evolution. Statistical approaches include log-likelihood ratio tests, score tests, generalized linear models, EM algorithm, Markov chain Monte Carlo, hidden Markov model, and classification and regression trees. Students may not receive credit for both MA 584 and MA 4603. (Prerequisite: knowledge of probability and statistics at the undergraduate level.)

Class materials are given at the web-based blackboard myWPI.

**MA546 Design & Analysis of Experiments**

Controlled experiments?studies in which treatments are assigned to observational units?are the gold standard of scientific investigation. The goal of the statistical design and analysis of experiments is to (1) identify the factors which most affect a given process or phenomenon; (2) identify the ways in which these factors affect the process or phenomenon, both individually and in combination; (3) accomplish goals 1 and 2 with minimum cost and maximum efficiency while maintaining the validity of the results. Topics covered in this course include the design, implementation and analysis of completely randomized complete block, nested, split plot, Latin square and repeated measures designs. Emphasis will be on the application of the theory to real data using statistical computer packages. (Prerequisite: knowledge of basic probability and statistics at the level of MA 511 is assumed.)

Class materials are given at the web-based blackboard myWPI.

**MA2611 Applied Statistics I**

Cat. I This course focuses on the theoretical foundations of ordinary equations while building models for physical and biological systems. Mathematical topics may include methods for solving systems of ordinary differential equations, existence and uniqueness theory, stability theory, phase-plane analysis and limit cycles. Examples will be chosen from electrical and mechanical oscillations, control theory, ecological models and reaction kinetics. Students will learn how to turn a real-life physical or biological problem into a mathematical one and to interpret the mathematical results. This course is designed primarily for Mathematical Sciences majors and those interested in the deeper mathematical issues underlying mathematical modeling. Undergraduate credit may not be earned both for this course and for MA 3431. Recommended background: MA 1024, MA 2051 and MA 2071.

Class materials are given at the web-based blackboard myWPI.

**MA2610 Applied Statistics for Life Sciences**

Cat. I This course is designed to introduce the student to statistical methods and concepts commonly used in the life sciences. Emphasis will be on the practical aspects of statistical design and analysis with examples drawn exclusively from the life sciences, and students will collect and analyze data. Topics covered include analytic and graphical and numerical summary measures, probability models for sampling distributions, the central limit theorem, and one and two sample point and interval estimation, parametric and non-parametric hypothesis testing, principles of experimental design, comparisons of paired samples and categorical data analysis. Undergraduate credit may not be earned for both this course and for MA 2611. Recommended background: MA 1022.

Class materials are given at the web-based blackboard myWPI.