Dr. Arne Gericke
John C. Metzger Professor
Worcester Polytechnic Institute
Department of Chemistry & Biochemistry
Dr. Arne Gericke
John C. Metzger Professor
Worcester Polytechnic Institute
Department of Chemistry & Biochemistry

Publications
60. Neumann, B.M., Kenney, D., Wen, Q., Gericke, A. (2018) “Microfluidic device as a facile in vitro tool to generate and investigate lipid gradients” Chem. Phys. Lipids 210: 109 – 121. PMID: 29102758
59. Han, K., Venable, R.M., Bryant, A.M., Legacy, C.J., Shen, R., Li, H. Roux, B., Gericke, A., Pastor, R. (2018) “Graph-Theoretic Analysis of Monomethyl Phosphate Clustering in Ionic Solutions” J. Phys. Chem B 122: 1484 – 1494. PMC: 6322214
58. Graber, Z.T., Thomas, J., Johnson, E., Gericke, A., Kooijman, E.E. (2018) “Effect of H-Bond Donor Lipids on Phosphatidylinositol-3,4,5-Trisphosphate Ionization and Clustering” Biophys. J. 114: 126 – 136. PMC: 5984899
57. Gericke, A. (2018) “Is Calcium Fine-Tuning Phosphoinositide-Mediated Signaling Events Through Clustering?” Biophys. J. 114: 2483 – 2484 PMID: 29874599
56. Oliveira, J.S.; Brezesinski, G.; Hill, A; Gericke, A (2016) “Influence of calcium on ceramide-1-phosphate monolayers” Beilstein J. Nanotechnol 7:236 – 245. PMC: 47785058
55. Heinrich, F., Chakravarthy, S., Nanda, H., Papa, A., Pandolfi, P. P., Ross, A. H., Harishchandra, R. K., Gericke, A., Loesche, M. (2015) “The PTEN tumor suppressor form homodimers in solution” Structure 23: 1952 -7. PMID: 26299948
54. R.K. Harishchandra, B.E. Neumann, A. Gericke, A.H. Ross (2015) “Biophysical methods for the characterization of PTEN/lipid bilayer interactions” Methods 77-78: 125-135. PMID: 25697761
53. E. Villarreal-Ramirez, R. Garduno-Juarez, A. Gericke, A. Boskey (2014) "The role of phosphorylation in dentin phosphoprotein peptide absorption to hydroxyapatite surfaces: a molecular dynamics study" Connect. Tissue Res. 55 Suppl. 1: 134 - 137 PMID25158198
52. E.E. Kooijman and A. Gericke (2014) "Physical chemistry and biophysics of polyphosphoinositide mediated lipid signaling" Chem. Phys. Lipids 182: 1 - 2. PMID 25077986
51. R. Pulido, ..., A. Gericke and 37 co-authors (2014) "A unified nomenclature and amino acid numbering for human PTEN" Sci. Signaling 7: pe15 PMID 24985344
50. Z. Jiang, R.E. Redfern, Y. Isler, A.H. Ross, A. Gericke (2014) "Cholesterol stabilizes fluid phosphoinositide domains" Chem. Phys. Lipids 182: 52 - 61. PMC24556334
49. Z.T. Graber, A. Gericke, E.E. Kooijman (2014) "Phosphatidylinositol-4,5-bisphosphate ionization in the presence of cholesterol, calcium or magnesium ions" Chem. Phys. Lipids 182: 62 - 72. PMID 24309195
48. A. Gericke, N.R. Leslie, M. Losche, A.H. Ross (2013)" PtdIns(4,5)P2-mediated cell signaling: emerging principles and PTEN as a paradigm for regulatory mechanism" Adv. Exp. Med. Biol. 991: 85 - 104 PMC 3763917
47. Z. Graber, Z. Jiang, A. Gericke, E.E. Koojman (2012) “Phosphatidylinositol-4,5-bisphosphate ionization and domain formation in the presence of lipids with hydrogen bond donor capabilities” Chem. Phys. Lip. 165: 696 – 704.
46. S. Shenoy, P. Shekhar, F. Heinrich, M.C. Daou, A. Gericke, A.H. Ross, M. Losches (2012) "Membrane association of the PTEN Tumor suppressor: Molecular Details of the protein-membrane complex from SPR binding studies and neutron reflection" PloS One 7(4): e32591 PMC 3323581
45. S.M Grant, S.M. Woods, A. Gericke, M. Jaroniec (2011) “Introduction of Bridging and Pendant Organic Groups into Mesoporous Alumina Materials” ACS Appl. Materials & Interfaces p. 4480 - 4486. PMID 21988174
44. A. Das, E. Soehnlein, S. Woods, R. Hegde, A. Henry, A. Gericke, S. Basu (2011) “VEGFR-2 targeted cellular delivery of doxorubicin by gold nanoparticles for potential antiangiogenic therapy” Journal of Nanoparticle Research,13: 6283 - 6290. Journal
43. R.E Redfern, M.-C. Daou, L. Li, M. Munson, A. Gericke, A. Ross (2010) “A mutant form of PTEN linked to autism” Protein Sci. 19: 1948 - 1956. PMID 20718038
42. A. Gericke, C. Qin, Y. Sun, R. Redfern, D. Redfern, Y. Fujimoto, H. Taleb, W.T. Butler, A.L. Boskey (2010) “Dentin Matrix Protein-1 fragments have distinct effects on in vitro mineralization” Journal of Dental Research 89: 355 – 359. PMID 20200415
41. E.E. Kooijman, M. Gangoda, A. Gericke (2009) “Ionization properties of phosphatidylinositolpolyphosphates in mixed model membranes” Biochemistry 48: 9360 - 9371. PMID 19725516
40. A. Ross, A. Gericke (2009) “Phosphorylation keeps PTEN phosphatase closed for business” Proc. Natl. Acad. Sci. 106: 1297 – 1298. PMID 19174524
39. E. E. Kooijman, D. Vaknin, W. Bu, L. Joshi, S.W. Kang, A. Gericke, E.K. Mann, S. Kumar (2009) “Structure of ceramide-1-phosphate at the air-water solution interface in the absence and presence of Ca2+” Biophys. J 96: 2204 – 2015. PMID 19289047
38. M.A. Radomski, E.G. Donnay, R. Mukherjee, D.A. Redfern, A. Gericke, D.S. Damron, N.E. Brasch (2008) “Vanadium B12 Bioconjugates as Potential Therapeutics for Treating Diseases” Chem. Communications 3783 – 3785. PMID 18685776
37. E.A. Büyüktanır, K. Zhang, A. Gericke and J.L.West (2008) Raman imaging of nematic and smectic liquid crystals“ Mol. Cryst. Liq. Cryst., 487: 39-51. Journal
36. R.E. Redfern, D.A. Redfern, M.L. Furgason, M. Munson, A.H. Ross, A. Gericke (2008) “Phosphoinositides selectively bind to PTEN phosphatase and induce structural changes” Biochemistry, 47: 2162 – 2171. PMID 18220422
35. E.E. Kooijman, J. Sot, L. Buth-Montes, A. Alonso, A. Gericke, B. de Kruijff, S. Kumar, F.M. Goni (2008) “Membrane organization and ionization behavior of the minor but crucial lipid ceramide-1-phosphate” Biophys. J. 94: 4320 – 4330. PMID 18296489
34. A. Gericke, Mary Munson, A. Ross (2006) “Regulation of PTEN phosphatase” Gene, 374:1-9. PMID 16675164
33. A. Gericke, C. Qin, L. Spevak, Y. Fujimoto, W.T. Butler, E. Sorensen, A.L. Boskey (2005) “Importance of Phosphorylation for Osteopontin regulation of Biomineralization” Calcified Tissue International 77: 45 -54. PMID 18220422
32. D.A. Redfern, A. Gericke (2005) “pH dependent microdomain formation in phosphatidylinositol polyphosphate/ phosphatidylcholine mixed vesicles”; J. Lip. Res. 46: 504 - 515. PMID 15604522
31. D.A. Redfern, A. Gericke (2004) “Domain formation in phosphatidylinositol monophosphate/ phosphatidylcholine model membrane systems” Biophys. J. 86: 2980 - 2992. PMID 15111413
30. J.W. Brauner, C.R. Flach, Z. Xu, X. Bi, R.N.A.H. Lewis, R.N.McElhaney, A. Gericke, R. Mendelsohn; (2003) “Quantitative functional group orientation in Langmuir films by Infrared Reflection Absorption Spectroscopy: C=O groups in behenic acid methyl ester and sn2 - 13C-DSPC” J. Phys. Chem. 107: 7202 - 7211. Journal
29. A. Gericke, G. Brezesinski, A. Blume; (2000) “Acyl Chain and Headgroup Orientation in Phosphoinositide Monolayers: An IRRAS and X-ray study” in: 12th International Conference on Fourier Transform Spectroscopy, Ed. M. Tasumi, Waseda University Press, p. 131 -132 (2000)
28. A. Gericke (2000) “Infrared Spectroscopic Characterization of Inositols and Inositolphosphates” in: 12th International Conference on Fourier Transform Spectroscopy; Ed. M. Tasumi, Waseda University Press, p. 461 - 462
27. C.R. Flach, A. Gericke, K.M.V. Keough, R. Mendelsohn (1999) “Palmitoylation of lung surfactant protein SP-C alters surface thermodynamics but not protein secondary structure or orientation in DPPC Langmuir films” Biochim. Biophys. Acta, 1416: 11 - 20. PMID 9889301
26. F. Wu; A. Gericke; C. Flach; T.R. Mealy-TR; B. A. Seaton-BA; R. Mendelsohn (1998) “Domain structure and molecular conformation in annexinV/ 1,2- dimyristoyl-sn- glycero-3-phosphate/Ca2+ aqueous monolayers: A brewster angle microscopy/ infrared reflection-absorption spectroscopy study” Biophysical Journal 74: 3273 - 3281. PMID 9635781
25. D. Dieudonné, A. Gericke, C. R. Flach, X. Jiang, R. S. Farid, R. Mendelsohn (1998) “Propensity for Helix formation in the Hydrophobic Peptides K2(LA)x (x= 6,8,10,12) in Monolayer, Bulk and Lipid-Containing Phases. Infrared and Circular Dichroism Studies” J. Am. Chem. Soc. 120: 792 - 799. Journal
24. A.Gericke, Elizabeth R. Smith, D.J. Moore, R. Mendelsohn, J. Storch (1997) “Adipocyte fatty acid binding protein: Interaction with phospholipid membranes and thermal stability studied by FT-IR spectroscopy” Biochemistry 36: 8311 - 8317. PMID 9204877
23. A. Gericke, C.R. Flach, R. Mendelsohn (1997) “Structure and orientation of lung surfactant SP-C and L-α-dipalmitoyl-phosphatidylcholine in aqueous monolayers” Biophys. J. 73: 492 – 499. PMID 9199811
22. C.R. Flach, A. Gericke, R. Mendelsohn (1997) “Quantitative determination of molecular tilt angles in monolayer films at the air/water interface: Infrared reflection-absorption spectroscopy of behenic acid methyl ester” J. Phys. Chem. 101: 58 - 65. Journal
21. S.J. Gadaletta, A. Gericke, A.L. Boskey, R. Mendelsohn (1996) “Two-dimensional infrared correlation spectroscopy of synthetic and biologic apatites” Biospectroscopy 2:353-364. Journal
20. A. Gericke, S.J. Gadaletta, J.W. Brauner, R. Mendelsohn (1996) “Characterization of biological samples by two-dimensional infrared spectroscopy: Simulation of frequency, bandwidth and intensity changes” Biospectroscopy 2: 341-351. Journal
19. J. Simon-Kutscher, A. Gericke, H. Hühnerfuss (1996) “Effect of bivalent Ba, Cu, Ni and Zn cations on the structure of octadecanoic acid monolayers at the air-water interface as determined by External Infrared Reflection-Absorption Spectroscopy” Langmuir 12:1027-1035. Journal
18. A. Gericke, D. Moore, R.K. Erukulla, R. Bittman, R. Mendelsohn (1996) “Partially deuterated phospholipids as IR structure probes of conformational order in bulk and monolayer phases” J. Mol. Structure 379: 227 - 239. Journal
17. A. Gericke and R. Mendelsohn (1996) “Partial chain deuteration as an IRRAS probe of conformational order of different regions in hexadecanoic acid monolayers at the air/water interface” Langmuir 12: 758 - 762. Journal
16. D. Moore, A. Gericke, R. Mendelsohn (1996) “Unusual conformational order fluctuations in mixed acyl chain membranes of Acholeplasma laidlawii B as measured by FT-IR Spectroscopy” Biochim. Biophys. Acta 1279: 49 - 57. PMID 8624360
15. A. Gericke, J.W. Brauner, R.K. Erukulla, R. Bittmann, R. Mendelsohn “In-situ investigation of partially deuterated fatty acid and phospholipid monolayers at the air/water interface by IR reflection-absorption spectroscopy” Thin Solid Films 284-285: 428-431. Journal
14. H. Hühnerfuss, A. Gericke, V. Neumann, K. Stine (1996)“The determination of the molecular order of chiral monolayers at the air/water interface by Infrared Reflection Absorption Spectroscopy (IRRAS) - A Bridge between Physico- and Biochemistry” Thin Solid Films 284-285: 694 - 697. Journal
13. R. Mendelsohn, J. Brauner, A. Gericke (1995) “External infrared reflection-absorption spectrometry of monolayer films at the air/water interface” Ann. Rev. Phys. Chem. 46: 305 - 334. Journal
12. V. Neuman, A. Gericke, H. Hühnerfuss (1995) “Comparison of enantiomeric and racemic monolayers of 2-hydroxyhexadecanoic acid by external infrared reflection-absorption spectroscopy” Langmuir 11: 2206 - 2213. Journal
11. A. Gericke and H. Hühnerfuss “The conformational order and headgroup structure of long-chain alkanoic acid ester monolayers at the air/water interface” Ber. Bunsenges. Phys. Chem. 99: 641 - 650. Journal
10. A. Gericke and H. Hühnerfuss (1995) “ Investigation of Z- and E-unsaturated fatty acids, fatty acid esters and fatty alcohols at the air/water interface by IR-spectroscopy” Langmuir 11: 225 - 230. Journal
9. A. Gericke and H. Hühnerfuss (1994) “IR reflection-absorption spectroscopy - a versatile tool for studying interfacial enzymatic processes” Chem. Phys. Lipids 74: 205 - 210. Journal
8. A. Gericke and H. Hühnerfuss (1994) “Infrared spectroscopic comparison of enantiomeric and racemic N-octadecanoylserine methyl ester monolayers at the air/water interface” Langmuir 10: 3782 - 3786. Journal
7. A. Gericke and H. Hühnerfuss (1994) “The effect of cations on the order of saturated fatty acid monolayers at the air/water interface as determined by infrared reflection-absorption spectroscopy” Thin Solid Films 245: 74 - 82. Journal
6. H. Hühnerfuss, A. Gericke, P.A. Lange, R. Theis, V. Wisman (1994) “Classification of natural sea slicks by multi-frequency radar techniques: new chemical insights and their geophysical implications” J. Geophys. Res. 99: 9835 - 9845. Journal
5. A. Gericke and H. Hühnerfuss (1993) “In situ investigation of saturated long chain fatty acid monolayers at the air/water interface by external infrared reflection-absorption spectroscopy” J. Phys. Chem. 97: 12899 - 12908. Journal
4. A. Gericke, J. Simon-Kutscher and H. Hühnerfuss “Comparison of different spreading techniques for monolayers at the air/water interface” Langmuir 9: 3115 - 3121. Journal
3. A. Gericke, J. Simon-Kutscher and H. Hühnerfuss (1993) “The influence of the spreading solvent on the properties of monolayers at the air/water interface” Langmuir 9: 2119 - 2127. Journal
2. A. Gericke, A.V. Michailov and H. Hühnerfuss (1993) “Polarized external infared reflection-absorption spectroscopy at the air/water interface:Comparison of experimental and theoretical results for different angles of incidence” Vib. Spectroscopy 4: 335 - 348. Journal
1. A. Gericke and H. Hühnerfuss (1989) “Thermal anomalies induced by monomolecular surface films” J. Colloid Interface Science 131: 588 - 591. Journal