Research TeachingServicePersonal

Selected Publications
    1. Mullen, C, Vaughan, T,  Billiar, K,  and McNamara, L, "The Effect of Substrate Stiffness, Thickness and Crosslinking Density on Osteogenic Cell Behaviour," Biophysical Journal, Accepted for publication.
    2. Cirka, H.A., Kural, M.H., and Billiar, K.L., “Mechanoregulation of Aortic Valvular Interstitial Cell Life and Death” Journal of long-term Effects of Medical Implants, Accepted for publication.
    3. Wang L, Wu Z, Yang C, Zheng J, Bach R, Muccigrosso D, Billiar K, Maehara A, Mintz GS, Tang D.,  “IVUS-Based FSI Models for Human Coronary Plaque Progression Study:  Components, Correlation and Predictive Analysis,” Ann Biomed Eng. 2014 Sep 23.
    4. Zhang, W., Billiar, K.L., and Sacks, M.S., “A generalized method for the analysis of planar biaxial mechanical data,” J Biomech Eng. 2014 Nov 1. doi: 10.1115/1.4029266.
    5. Fan  R., Tang  D., Yang  C., Zheng  J., Bach  R., Wang  L., Muccigrosso  D., Billiar  K., Zhu  J., Ma  G., Maehara  A., Mintz S G., “Human coronary plaque wall thickness correlated positively with flow shear stress and negatively with plaque wall stress: an IVUS-based fluid-structure interaction multi-patient study,” BioMedical Engineering OnLine, 13(32), 2014.
    6. Kural, M.H. and Billiar, K.L., “Mechanoregulation of valvular interstitial cell phenotype in the third dimension,” Biomaterials, Jan;35(4):1128-37, 2014. doi: 10.1016/j.biomaterials.2013.10.047.
    7. Kural, M.H. and Billiar, K.L., “Regulating tension in three-dimensional culture environments.” (Invited review) Experimental Cell Research, 319(16), 2013.  DOI: 0.1016/j.yexcr.2013.06.019.
    8. Billiar, K., Oliva, T., Hubelbank, J., and Camesano, T., “Teaching STEM by Design,” Advances in Engineering Education, V4(1) Winter 2014.  Chosen as lead article and featured in the ASEE PRISM magazine.
    9. Rudnicki, M., Cirka, H., Aghvami, M., Sander, E.A., Wen, Q. and Billiar, K.L., “Nonlinear strain stiffening is not sufficient to explain how far cells can “feel” on fibrous protein gels,” Biophysical Journal, 105(1):11-20, 2013.
    10. Tang D, Yang C, Geva T, Rathod R, Yamauchi H, Gooty V, Tang A, Kural MH, Billiar KL, Gaudette G, Del Nido PJ., “A multiphysics modeling approach to develop right ventricle pulmonary valve replacement surgical procedures with a contracting band to improve ventricle ejection fraction,” Computers and Structures 2013 Jun 1;122:78-87.
    11. Tang D, Yang C, Zheng J, Canton G, Bach RG, Hatsukami TS, Wang L, Yang D, Billiar KL, Yuan C, “Image-Based Modeling and Precision Medicine: Patient-Specific Carotid and Coronary Plaque Assessment and Predictions,” IEEE Transactions on Biomedical Engineering 2013 Mar;60(3):643-51. doi: 10.1109/TBME.2013.2242891.
    12. Adebayo O, Hu JZ, Gwyther TA, Billiar KL, Rolle MW.  “Self-assembled smooth muscle cell tissue rings exhibit greater tensile strength than cell-seeded fibrin or collagen gel rings.” Journal of Biomedical Materials Research, Part A. 2013 Feb;101(2):428-37. doi: 10.1002/jbm.a.34341.
    13. Yang, C., Tang, D., Geva, T., Rathod, R., Yamauchi, H., Gooty, V., Tang, A., Gaudette, G., Billiar, K.L., Kural, M., del Nido, P., “Using contracting band to improve right ventricle ejection fraction for patients with repaired Tetralogy of Fallot, a modeling study using patient-specific CMR-based two-layer anisotropic models of human right and left ventricles.” The Journal of Thoracic and Cardiovascular Surgery. 2013 Jan;145(1):285-93, 293.e1-2. doi: 10.1016/j.jtcvs.2012.03.009.
    14. Throm Quinlan, A., Billiar, K.L., “Investigating the role of stiffness in the persistence of valvular interstitial cell activation.” Journal of Biomedical Materials Research Part A. 2012 Sep;100(9):2474-82. doi: 10.1002/jbm.a.34162.
    15. Cirka, H., Koehler, S., Farr, W., Billiar, K.L., “Eccentric rheometry for viscoelastic characterization of small, soft, anisotropic, and irregularly shaped biopolymer gels and tissue biopsies.” Annals of Biomedical Engineering Ann Biomed Eng. 2012, 40 (8) PMID:  22361829.
    16. Liu, H., Canton, G., Yuan, C., Yang, C., Billiar, K.L., Teng, Z., Hoffman, H., Tang, D., “Using In Vivo Cine and 3D Multi-Contrast MRI to Determine Human Atherosclerotic Carotid Artery Material Properties and Circumferential Shrinkage Rate and Their Impact on Stress/Strain Predictions.” Journal of Biomechanical Engineering. 2012 Jan;134(1):011008; selected as a 2012 Editors’ Choice Paper
    17. Liu, H., Cai, M., Yang, C., Zheng, J., Bach, R., Kural, M.,  Billiar, K.L., Muccigrosso, D., Lu, D., Tang, D., “IVUS-Based Computational Modeling and Planar Biaxial Artery Material Properties for Human Coronary Plaque Vulnerability Assessment.” Molecular & Cellular Biomechanics (MCB). Mol Cell Biomech. 2012 Mar;9(1):77-93.
    18. Cai, M., Yang, C., Kural, M., Bach, R., Muccigrosso, D., Yang, D., Zheng, J., Billiar, K.L., Tang, D., “Intravascular ultrasound (IVUS)-based computational modeling and planar biaxial artery material properties for human coronary plaque vulnerability assessment.” International Conference on Computer Engineering & Systems (ICCES), 2012 vol.19, no.4, pp. 97-104
    19. Broderick G, McIntyre J, Noury M, Strom HM, Psoinos C, Christakas A, Billiar K, Hurwitz ZM, Lalikos JF, Ignotz RA, Dunn RM. “Dermal Collagen Matricies for Ventral Hernia Repair:  Comparative Analysis in a Rat Model Hernia,” Hernia. 2012, Jun;16(3):333-43. DOI: 10.1007/s10029-011-0891-0
    20. Gwyther TA, Hu JZ, Billiar, K.L., Rolle MW.,"Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering" Journal of Visualized Experiments, JoVE 2011, Issue 57 doi: 10.3791/3366, http://www.jove.com/video/3366 .
    21. Kural, M.H., Cai, M.,  Tang, D., Gwyther, T., Zheng, J. and Billiar, K.L., “Planar biaxial characterization of diseased human coronary and carotid arteries for computational modeling,” Journal of Biomechanics, 2012 Mar 15;45(5):790-8 http://dx.doi.org/10.1016/j.jbiomech.2011.11.019
    22. Throm Quinlan, A.M., Sierad, L.N., Capulli, A.K., Firstenberg, L.E., and Billiar, K.L., “Combining dynamic stretch and tunable stiffness to probe cell mechanobiology in vitro,” PLoS ONE 6(8): e23272, 2011. doi:10.1371/journal.pone.0023272.
    23. Abu-Rub, M., Billiar, K., van Es, M., Knight, A., Rodriquez, B., Zeugolis, D., McMahon, S., Windebank, A., and Pandit, A., “Nano-textured self-assembled aligned collagen hydrogels promote directional neurite guidance and overcome inhibition by myelin associated glycoprotein” Soft Matter, 2011, 7, 2770-2781. DOI: 10.1039/C0SM01062F
    24. Gwyther TA, Hu JZ, Christakis AG, Skorinko JK, Shaw SM, Billiar, K.L., Rolle MW., “Engineered vascular tissue fabricated from aggregated smooth muscle cells,” Cells Tissues Organs. 2011.
    25. Silva JA, McCormick JJ, Reed MA, Morse AS, Heffernan MJ, Lavado RD, Billiar K, Wixted JJ., “Biomechanical effects of harvesting bone graft with the Reamer/Irrigator/Aspirator on the adult femur: a cadaver study,“ Injury. 2010 Nov;41 Suppl 2:S85-9.
    26. McCormick, J., Li, X., Weiss, D., Billiar, K.L. and Wixted, J., “Biomechanical Investigation of a Novel Ratcheting Arthrodesis Nail,” Journal of Orthopedic Surgery and Research., 2010, 5:74
    27. Broderick G, Lalikos J, Chowaniec M, Collins M, Wilson E, Babbitt R, O'Brien J, Billiar K, Dunn RM., “Femur Flap for Tibial Reconstruction: Percent Circumference Required to Convey a Mechanical Advantage over the Fibula.” J Reconstr Microsurg. 26(7), pp. 481-6, 2010. PMID: 20593345
    28. Yao L, Billiar K, Windebank AJ, Pandit A., “Multi-channelled Collagen Conduits for Peripheral Nerve Regeneration: Design, Fabrication and Characterization,” Tissue Eng Part C Methods. 2010 Jun 9; doi:10.1089/ten.TEC.2010.0152; PMID: 20528663.
    29. Balestrini, J., Skorinko, J., Hera, A., Gaudette, G., and Billiar, K., “Applying controlled inhomogeneous deformation for in vitro mechanobiological studies,” Biomechan Model Mechanobiol, Volume 9(3):329-44, 2010. DOI 10.1007/s10237-009-0179-9; PMID: 20169395
    30. Peck, L., Billiar, K.L., Ray, M., “Dynamic Failure Properties of the Porcine Medial Collateral Ligament-Bone Complex for Predicting Injury in Automotive Collisions,” The Open Biomedical Engineering Journal, Open Biomed Eng J. 2010 Mar 9;4:77-84; doi: 10.2174/1874120701004010077; PMID: 20461229
    31.  John, J., Throm, A., Silvestri, C., Billiar, K.L., “Boundary stiffness regulates fibroblast behavior in collagen gels,” Annals of Biomedical Engineering. 2010 Mar;38(3):658-73. doi:10.1007/s10439-009-9856-1; PMID: 20012205.
    32. Yang, C., Bach, R.G., Zheng, J., Naqa, I.E., Woodard, P.K., Teng, Z., Billiar, K., Tang, D., “In Vivo IVUS-Based 3-D Fluid–Structure Interaction Models With Cyclic Bending and Anisotropic Vessel Properties for Human Atherosclerotic Coronary Plaque Mechanical Analysis,” IEEE Transactions On Biomedical Engineering, Vol. 56, No. 10, October 2009; doi: : 10.1109/TBME.2009.2025658; PMID: 19567341.
    33. Tang, D., Yang, C., Kobayashi, S., Zheng, J., Woodard, P., Teng, Z., Billiar, K., Bach, R., Ku, D., “3D MRI-Based Anisotropic FSI Models with Cyclic Bending for Human Coronary Atherosclerotic Plaque Mechanical Analysis,” Journal of Biomechanical Engineering, 2009 Jun;131(6):061010; doi: 10.1115/1.3127253; PMID: 19449964.
    34. Throm, A., Liu, W., Lock, C., and Billiar, K.L., “Development of a cell-derived matrix: effects of epidermal growth factor in chemically defined culture,” Journal of Biomedical Material Research, Part A. 2010 Feb 92(2):533-41, DOI: 10.1002/jbm.a.32369. PMID:19235212
    35. Balestrini, J., Billiar, K., “Magnitude and duty cycle of equibiaxial stretch modulates fibroblast remodeling of fibrin gel tissue equivalents,” Journal of Biomechanical Engineering. 2009 May;131(5):051005. URL: http://link.aip.org/link/?JBY/131/051005
    36. Pai, S., Dunn, R.,  Babbitt, R., Strom, H., Pins, G., Lalikos, J., Billiar, K.L., “Characterization of forces on the sternal midline following median sternotomy in a porcine model,” Journal of Biomechanical Engineering, 2008 Oct;130(5):051004.
    37. Marturano, J., Cleveland, B., Byrne, M., Wixted, J., Billiar, K., “An improved device for repeatable murine femur fracture for bone healing studies,” Journal of Biomechanics, 41(6), pp. 1222-8, 2008.

    38.   Grouf, J., Throm, A., Balestrini, J., Bush, K., and Billiar, K.L., “Differential effects of EGF and TGF-b1 on fibroblast activity in fibrin-based tissue equivalents,” Tissue Engineering, Vol.13 (4), pp. 799-807, 2007.

    39.   Pai, S., Gunja, N., Dupak, E., McMahon, N., Coburn J., Roth, T., Lalikos, J., Dunn, R., Francalancia, N., Pins, P., Billiar, K.L.., “A Mechanical Study of Rigid Plate Configurations for Sternal Fixation,” Annals of Biomedical Engineering, Vol. 35(5):808-16, 2007.

    40.   Ahlfors, J., Billiar, K.L., “Biomechanical and biochemical characteristics of a human fibroblast-produced and remodeled matrix,” Biomaterials, Vol. 28, pp. 2183–2191, 2007.

    41.   Coburn, J., Brody, S., Billiar, K.L., Pandit, A., “Biaxial Mechanical Evaluation of Cholecyst-Derived Extracellular Matrix: A Weakly-anisotropic Potential Tissue Engineered Biomaterial,” Journal of Biomedical Materials Research Part A, 81A (1): 250-256, 2007.

    42.   Balestrini, J., Billiar, K.L., “Equibiaxial cyclic stretch stimulates fibroblasts to rapidly remodel fibrin gels.” Journal of Biomechanics, Vol. 39, pp. 2983-2990, 2006.

    43.   Pai, S., Gunja, N., Dupak, E., McMahon, N., Roth, T., Lalikos, J., Dunn, R., Francalancia, N., Pins, P., Billiar, K.L., “In vitro comparison of wire and plate fixation for midline sternotomies,” Annals of Thoracic Surgery, Vol. 80, pp. 962-968, 2005.

    44.   Billiar, K.L., Throm, A.M., Frey, M.T., “Biaxial failure properties of planar living tissue equivalents,” Journal of Biomedical Materials Research, Vol.73A, pp. 182-191, 2005.

    45.   Billiar, K.L., Murray, J., Laude, D., Abraham, G., Bachrach, N., “Effects of carbodiimide crosslinking conditions on the physical properties of laminated intestinal submucosa,” Journal of Biomedical Materials Research., Vol. 56, No. 1, pp. 101-8, 2001.

    46.   Abraham, G.A., Murray, J., Billiar, K.L., Sullivan, S.J., "Evaluation of the porcine collagen layer as a biomaterial," Journal of Biomedical Materials Research., Vol. 51, pp. 442-452, 2000.

    47.   Gloeckner, D.C., Sacks, M.S., Billiar, K.L., Bachrach, N., "Mechanical evaluation and design of a multi-layered collagenous repair biomaterial," Journal of Biomedical Materials Research., Vol. 52, No. 2, pp. 365-373, 2000.

    48.   Billiar, K.L. and Sacks, M.S.  “Biaxial mechanical properties of the natural and glutaraldehyde treated porcine aortic valve: Part I - Experimental results," Journal of Biomechanical Engineering, Vol. 122, No. 1, pp. 23-30, 2000.

    49.   Billiar, K.L. and Sacks, M.S.  “Biaxial mechanical properties of the native and glutaraldehyde-treated aortic valve cusp: Part II - A structural constitutive model," Journal of Biomechanical Engineering, Vol. 122, No. 4, pp. 327-335, 2000.

    50.   Gloeckner, D.C., Billiar, K.L., Sacks, M.S., "Effects of mechanical fatigue on the bending properties of the porcine bioprosthetic heart valve," ASAIO Journal, Vol. 45, No. 1, pp. 59-63, 1999.

    51.   Billiar, K.L. and Sacks, M.S.  “A method to quantify the fiber kinematics of planar tissues under biaxial stretch,” Journal of Biomechanics, Vol. 30, No. 7, pp. 753-756, 1997.

 


 
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